Clinical Research

SpOtOn’s reagents and services are the end-result of many years of clinical research by Professor Dalton and Dr Turner. Their work has covered the different areas of SpOtOn’s product offer. Selected publications are presented below.


Daniel YA., Turner C., Haynes RM., Hunt BJ., Dalton RN. (2005) Rapid and Specific Detection of Clinically Significant Haemoglobinopathies Using Electrospray Mass Spectrometry-Mass Spectrometry. British Journal of Haematology. 130, 635-643.

Daniel YA., Turner C., Haynes RM., Hunt BJ., Dalton RN. (2007) Quantification of Hemoglobin A2 by Tandem Mass Spectrometry. Clinical Chemistry, 53,8 (2007) 144.

Daniel Y., Turner C., Farrar L., Dalton RN. (2008) A Comparison of IEF and MSMS for Clinical Hemoglobinopathy Screening in 40,000 Newborns. Blood (ASH Annual Meeting Abstracts). 112, 2387.

Daniel YA. (2010) The Use of Mass Spectrometry in Population Screening of the Clinically Significant Haemoglobinopathies. Thesis for Doctor of Philosophy, Kings College London.


Dalton, R. N., M. J. Wiseman, et al. (1988). "Measurement of urinary para-aminohippuric acid in glycosuric diabetics." Kidney International 34(1): 117-120.

Schultz, C. J., R. N. Dalton, et al. (2000). "Freezing method affects the concentration and variability of urine proteins and the interpretation of data on microalbuminuria. The Oxford Regional Prospective Study Group." Diabetic Medicine 17(1): 7-14.

Lawson, N., T. Lang, et al. (2002). "Creatinine assays: time for action?" Annals of Clinical Biochemistry 39(Pt 6): 599-602

Amin, R., C. Turner, et al. (2005). "The relationship between microalbuminuria and glomerular filtration rate in young type 1 diabetic subjects: The Oxford Regional Prospective Study." Kidney International 68(4): 1740-1749.

Dunger DB, Schwarze CP, Cooper JD, Widmer B, Neil HAW, Shield J, Edge JA, Jones TW, Daneman D, Dalton RN. (2007) Should we be identifying adolescents at high risk for nephropathy before the development of microalbuminuria? Diabetic Medicine, 24, 131-136

Preiss, D. J., I. M. Godber, et al. (2007). "The influence of a cooked-meat meal on estimated glomerular filtration rate." Annals of Clinical Biochemistry 44(Pt 1): 35-42.

  Nephrotoxicity continued . . .

Ansquer JC, Dalton RN, Causse E, Crimet D, Le Malicot K, Foucher C (2008) Effect of fenofibrate on kidney function: a 6-week randomized crossover trial in healthy people. American Journal of Kidney Diseases, 51, 904-913

Dalton, R. N. (2010). "Serum Creatinine and Glomerular Filtration Rate: Perception and Reality." Clinical Chemistry 56(5): 687-689.
Dalton, R. N. and C. Turner (2010). "Development of a reference MS/MS method for plasma creatinine." Clinica Chimica Acta 411(11-12): 904-905.

Metabolite screening

Collins JE, Nicholson NS, Dalton N, Leonard JV (1994) Biotinidase deficiency: early neurological presentation. Dev Med Child Neurol, 36, 268-270.

Steinberg SJ, Fensom AH, Dalton NR, Toseland PA, Kennedy CR, Mowat AP (1994) Measurement of plasma very long-chain fatty acids as a preliminary screening procedure for the diagnosis of peroxisomal disorders. J Inherited Metab Dis, 17, 323-326.

Alagratnam, D., A. S. Wierzbicki, et al. (2000). "Serum homocysteine, folate and thermolabile variant of MTHFR in healthy Sri Lankans living in London." Atherosclerosis 149(1): 221-222.

Dalton RN (2002) Appropriate metabolic investigations for the autistic child. BIMDG Bulletin, 22, 28-29.

Wraige, E., M. P. Champion, et al. (2002). "Fat oxidation defect presenting with overwhelming ketonuria." Archives of Disease in Childhood 87(5): 428-429.

Aledo R, Mir C, Dalton RN, Turner C, Pie J, Hegardt FG, Casals N, Champion MP (2006) Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency. Journal of Inherited Metabolic Disease, 29, 207-211.

Khalid, J. M., J. Oerton, et al. (2010). "Relationship of Octanoylcarnitine Concentrations to Age at Sampling in Unaffected Newborns Screened for Medium-Chain Acyl-CoA Dehydrogenase Deficiency." Clinical Chemistry 56(6): 1015-1021.